Chi-un Choe, MD; co-principle investigator (Department of Neurology)
Contact
Phone:

Fax:
+49-(0)40-7410-56651

+49-(0)40-7410-56263

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Publications
Homoarginine and Cardiovascular Outcome in the Population-Based Dallas Heart Study.
Atzler D, Gore MO, Ayers CR, Choe CU, Böger RH, de Lemos JA, McGuire DK, Schwedhelm E.
Arterioscler Thromb Vasc Biol. 2014 Sep 4. pii: ATVBAHA.114.304398.

Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.
Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E.
Circulation. 2013 Sep 24;128(13):1451-61. doi: 10.1161/CIRCULATIONAHA.112.000580. Epub 2013 Sep 4.

Homoarginine - An independent marker of mortality in heart failure.
Atzler D, Rosenberg M, Anderssohn M, Choe CU, Lutz M, Zugck C, Böger RH, Frey N, Schwedhelm E.
Int J Cardiol. 2013 Jul 24. pii: S0167-5273(13)01310-7.

Differential regulation of AMPK activation in leptin- and creatine-deficient mice.
Stockebrand M, Sauter K, Neu A, Isbrandt D, Choe CU.
FASEB J. 2013 Jun 28.

Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.
Nabuurs CI, Choe CU, Veltien A, Kan HE, Van Loon LJ, Rodenburg RJ, Matschke J, Wieringa B, Kemp GJ, Isbrandt D, Heerschap A.
J Physiol. 2012 Nov 5

L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome.
Choe CU, Nabuurs C, Stockebrand MC, Neu A, Nunes P, Morellini F, Sauter K, Schillemeit S, Hermans-Borgmeyer I, Marescau B, Heerschap A, Isbrandt D.
Hum Mol Genet. 2012 Oct 9. (PDF)

CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.
Choe CU, Lardong K, Gelderblom M, Ludewig P, Leypoldt F, Koch-Nolte F, Gerloff C, Magnus T.
PLoS One. 2011;6(5):e19046.
PDF (506K)

Nitroxyl in the central nervous system.
Choe CU, Lewerenz J, Gerloff C, Magnus T, Donzelli S.
Antioxid Redox Signal. 2011 May 1;14(9):1699-711.

Multiple cerebral cavernous malformations and a novel CCM3 germline deletion in a German family.
Choe CU, Riant F, Gerloff C, Tournier-Lasserve E, Orth M.
J Neurol. 2010 Dec;257(12):2097-8.

Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.
Leypoldt F, Choe CU, Gelderblom M, von Leitner EC, Atzler D, Schwedhelm E, Gerloff C, Sydow K, Böger RH, Magnus T.
PLoS One. 2009 Oct 7;4(10):e7337.
Free article at journal site

Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.
Choe CU, Lewerenz J, Fischer G, Uliasz TF, Espey MG, Hummel FC, King SB, Schwedhelm E, Böger RH, Gerloff C, Hewett SJ, Magnus T, Donzelli S.
J Neurochem. 2009 Sep;110(6):1766-73.

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.
Gelderblom M, Leypoldt F, Steinbach K, Behrens D, Choe CU, Siler DA, Arumugam TV, Orthey E, Gerloff C, Tolosa E, Magnus T.
Stroke. 2009 May;40(5):1849-57.

Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.
Geng L, Boehmerle W, Maeda Y, Okuhara DY, Tian X, Yu Z, Choe CU, Anyatonwu GI, Ehrlich BE, Somlo S.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15920-5.
Free article in PMC | at journal site

The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork.
Choe CU, Ehrlich BE.
Sci STKE. 2006 Nov 28;2006(363):re15.

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D.
Hum Mol Genet. 2006 Oct 1;15(19):2888-902.
Free article at journal site

Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons.
Jacob SN, Choe CU, Uhlen P, DeGray B, Yeckel MF, Ehrlich BE.
J Neurosci. 2005 Mar 16;25(11):2853-64.
Free article at journal site

Functional coupling of chromogranin with the inositol 1,4,5-trisphosphate receptor shapes calcium signaling.
Choe CU, Harrison KD, Grant W, Ehrlich BE.
J Biol Chem. 2004 Aug 20;279(34):35551-6.
PMID: 15194698 [PubMed - indexed for MEDLINE]
Free article at journal site

A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.
Thrower EC, Choe CU, So SH, Jeon SH, Ehrlich BE, Yoo SH.
J Biol Chem. 2003 Dec 12;278(50):49699-706.
Free article at journal site