Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.
Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.
Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664.

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.
J Neurosci. 2013 Aug 7;33(32):12915-12928.

Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.
Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E.
Circulation. 2013 Sep 24;128(13):1451-61. doi: 10.1161/CIRCULATIONAHA.112.000580. Epub 2013 Sep 4.

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.
J Neurosci. 2013 Aug 7;33(32):12915-12928.

Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C.
Sci Transl Med. 2013 Aug 7;5(197):197ra104.

Differential regulation of AMPK activation in leptin- and creatine-deficient mice.
Stockebrand M, Sauter K, Neu A, Isbrandt D, Choe CU.
FASEB J. 2013 Jun 28.

Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.
Nabuurs CI, Choe CU, Veltien A, Kan HE, Van Loon LJ, Rodenburg RJ, Matschke J, Wieringa B, Kemp GJ, Isbrandt D, Heerschap A.
J Physiol. 2012 Nov 5

L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome.

Choe CU, Nabuurs C, Stockebrand MC, Neu A, Nunes P, Morellini F, Sauter K, Schillemeit S, Hermans-Borgmeyer I, Marescau B, Heerschap A, Isbrandt D.
Hum Mol Genet. 2012 Oct 9. (PDF)

Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.
Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.
Channels (Austin). 2011 May-Jun;5(3):251-61. Epub 2011 May 1.

A homozygous SCN5A mutation in a severe, recessive type of cardiac conduction disease.
Neu A, Eiselt M, Paul M, Sauter K, Stallmeyer B, Isbrandt D, Schulze-Bahr E.
Hum Mutat. 2010 Jun 17.
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Control of heart rate by cAMP sensitivity of HCN channels.
Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12189-94. Epub 2009 Jul 1.
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The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Sawallisch C, Berhörster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp HJ.
J Biol Chem. 2009 Apr 3;284(14):9225-36.

In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes.
Heerschap A, Kan HE, Nabuurs CI, Renema WK, Isbrandt D, Wieringa B.
Subcell Biochem. 2007;46:119-48. Review.

Creatine uptake in mouse hearts with genetically altered creatine levels.
ten Hove M, Makinen K, Sebag-Montefiore L, Hunyor I, Fischer A, Wallis J, Isbrandt D, Lygate C, Neubauer S.
J Mol Cell Cardiol. 2008 Sep;45(3):453-9. Epub 2008 Jun 10.
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Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study.
Schneider JE, Stork LA, Bell JT, ten Hove M, Isbrandt D, Clarke K, Watkins H, Lygate CA, Neubauer S.
J Cardiovasc Magn Reson. 2008 Feb 6;10(1):9.
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Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy.
Kan HE, Meeuwissen E, van Asten JJ, Veltien A, Isbrandt D, Heerschap A.
J Appl Physiol. 2007 Jun;102(6):2121-7. Epub 2007 Mar 8.
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C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D.
Hum Mol Genet. 2006 Oct 1;15(19):2888-902. Epub 2006 Aug 21.
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Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected]
Callsen B, Isbrandt D, Sauter K, Hartmann LS, Pongs O, Bähring R.
J Physiol. 2005 Oct 15;568(Pt 2):397-412. Epub 2005 Aug 11. Erratum in: J Physiol. 2005 Nov 1;568(Pt 3):1067.
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Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice.
ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S.
Circulation. 2005 May 17;111(19):2477-85. Epub 2005 May 9.
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Biochemical and behavioural phenotyping of a mouse model for GAMT deficiency.
Torremans A, Marescau B, Possemiers I, Van Dam D, D'Hooge R, Isbrandt D, De Deyn PP.
J Neurol Sci. 2005 Apr 15;231(1-2):49-55.
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Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice.
Kan HE, Buse-Pot TE, Peco R, Isbrandt D, Heerschap A, de Haan A.
Am J Physiol Cell Physiol. 2005 Jul;289(1):C113-9. Epub 2005 Mar 2.
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Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.
Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D.
Nat Neurosci. 2005 Jan;8(1):51-60. Epub 2004 Dec 19.
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In vivo cardiac 1H-MRS in the mouse.
Schneider JE, Tyler DJ, ten Hove M, Sang AE, Cassidy PJ, Fischer A, Wallis J, Sebag-Montefiore LM, Watkins H, Isbrandt D, Clarke K, Neubauer S.
Magn Reson Med. 2004 Nov;52(5):1029-35.

Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes.
Steinfeld R, Steinke HB, Isbrandt D, Kohlschütter A, Gärtner J.
Hum Mol Genet. 2004 Oct 15;13(20):2483-91. Epub 2004 Aug 18.
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Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase.
Kan HE, Renema WK, Isbrandt D, Heerschap A.
J Physiol. 2004 Oct 1;560(Pt 1):219-29. Epub 2004 Jul 29.
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Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency.
Schmidt A, Marescau B, Boehm EA, Renema WK, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, Ullrich K, Waldschütz R, Heerschap A, De Deyn PP, Neubauer S, Isbrandt D.
Hum Mol Genet. 2004 May 1;13(9):905-21. Epub 2004 Mar 17.
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Effective long-term control of cardiac events with beta-blockers in a family with a common LQT1 mutation.
Wedekind H, Schwarz M, Hauenschild S, Djonlagic H, Haverkamp W, Breithardt G, Wülfing T, Pongs O, Isbrandt D, Schulze-Bahr E.
Clin Genet. 2004 Mar;65(3):233-41.
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Biophysical properties of Kv3.1 channels in SH-SY5Y human neuroblastoma cells.
Friederich P, Dilger JP, Isbrandt D, Sauter K, Pongs O, Urban BW.
Receptors Channels. 2003;9(6):387-96.
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N-type inactivation features of Kv4.2 channel gating.
Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, Bähring R.
Biophys J. 2004 Jan;86(1 Pt 1):210-23.
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Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.
Friederich P, Solth A, Schillemeit S, Isbrandt D.
Br J Anaesth. 2004 Jan;92(1):93-101.
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