Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.
Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.
Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664. PDF

Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C.
Sci Transl Med. 2013 Aug 7;5(197):197ra104.

A homozygous SCN5A mutation in a severe, recessive type of cardiac conduction disease.
Neu A, Eiselt M, Paul M, Sauter K, Stallmeyer B, Isbrandt D, Schulze-Bahr E.
Hum Mutat. 2010 Jun 17.
PDF

Control of heart rate by cAMP sensitivity of HCN channels.
Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12189-94. Epub 2009 Jul 1.
PDF

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D.
Hum Mol Genet. 2006 Oct 1;15(19):2888-902. Epub 2006 Aug 21.
Free article at journal site


Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction
Callsen B, Isbrandt D, Sauter K, Hartmann LS, Pongs O, Bähring R.
J Physiol. 2005 Oct 15;568(Pt 2):397-412. Epub 2005 Aug 11. Erratum in: J Physiol. 2005 Nov 1;568(Pt 3):1067.
Free article in PMC | at journal site


Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.
Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D.
Nat Neurosci. 2005 Jan;8(1):51-60. Epub 2004 Dec 19.
Free PDF


Effective long-term control of cardiac events with beta-blockers in a family with a common LQT1 mutation.
Wedekind H, Schwarz M, Hauenschild S, Djonlagic H, Haverkamp W, Breithardt G, Wülfing T, Pongs O, Isbrandt D, Schulze-Bahr E.
Clin Genet. 2004 Mar;65(3):233-41.
PDF


Biophysical properties of Kv3.1 channels in SH-SY5Y human neuroblastoma cells.
Friederich P, Dilger JP, Isbrandt D, Sauter K, Pongs O, Urban BW.
Receptors Channels. 2003;9(6):387-96.
PDF


N-type inactivation features of Kv4.2 channel gating.
Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, Bähring R.
Biophys J. 2004 Jan;86(1 Pt 1):210-23.
Free article in PMC | at journal site


Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.
Friederich P, Solth A, Schillemeit S, Isbrandt D.
Br J Anaesth. 2004 Jan;92(1):93-101.
Free article at journal site


Pacemaker channel dysfunction in a patient with sinus node disease.
Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D.
J Clin Invest. 2003 May;111(10):1537-45.
Free article in PMC | at journal site


Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism.
Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, Isbrandt D.
Neurobiol Dis. 2002 Nov;11(2):298-307.
PDF


Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.
Isbrandt D, Friederich P, Solth A, Haverkamp W, Ebneth A, Borggrefe M, Funke H, Sauter K, Breithardt G, Pongs O, Schulze-Bahr E.
J Mol Med. 2002 Aug;80(8):524-32. Epub 2002 Jun 28.
PDF


A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype.
Schulze-Bahr E, Schwarz M, Hauenschild S, Wedekind H, Funke H, Haverkamp W, Breithardt G, Pongs O, Isbrandt D.
J Mol Med. 2001 Sep;79(9):504-9. Erratum in: J Mol Med 2001 Sep;79(9):547.
PDF


Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.
Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D.
J Biol Chem. 2001 Jun 29;276(26):23888-94. Epub 2001 Apr 3.
Free article at journal site


Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).
Isbrandt D, Leicher T, Waldschütz R, Zhu X, Luhmann U, Michel U, Sauter K, Pongs O.
Genomics. 2000 Mar 1;64(2):144-54.
PDF


Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current.
Zhu XR, Wulf A, Schwarz M, Isbrandt D, Pongs O.
Receptors Channels. 1999;6(5):387-400.


Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel.
Leicher T, Bähring R, Isbrandt D, Pongs O.
J Biol Chem. 1998 Dec 25;273(52):35095-101.
Free article at journal site